BClustLonG - A Dirichlet Process Mixture Model for Clustering Longitudinal Gene Expression Data

Many clustering methods have been proposed, but most of them cannot work for longitudinal gene expression data. 'BClustLonG' is a package that allows us to perform clustering analysis for longitudinal gene expression data. It adopts a linear-mixed effects framework to model the trajectory of genes over time, while clustering is jointly conducted based on the regression coefficients obtained from all genes. To account for the correlations among genes and alleviate the high dimensionality challenges, factor analysis models are adopted for the regression coefficients. The Dirichlet process prior distribution is utilized for the means of the regression coefficients to induce clustering. This package allows users to specify which variables to use for clustering (intercepts or slopes or both) and whether a factor analysis model is desired. More details about this method can be found in Jiehuan Sun, et al. (2017) <doi:10.1002/sim.7374>.

Last updated 5 years ago

openblascpp

2.00 score 3 scripts 191 downloads

PJFM - Variational Inference for High-Dimensional Joint Frailty Model

Joint frailty models have been widely used to study the associations between recurrent events and a survival outcome. However, existing joint frailty models only consider one or a few recurrent events and cannot deal with high-dimensional recurrent events. This package can be used to fit our recently developed penalized joint frailty model that can handle high-dimensional recurrent events. Specifically, an adaptive lasso penalty is imposed on the parameters for the effects of the recurrent events on the survival outcome, which allows for variable selection. Also, our algorithm is computationally efficient, which is based on the Gaussian variational approximation method.

Last updated 3 months ago

openblascpp

1.00 score 452 downloads

VBJM - Variational Inference for Joint Model

The shared random effects joint model is one of the most widely used approaches to study the associations between longitudinal biomarkers and a survival outcome and make dynamic risk predictions using the longitudinally measured biomarkers. One major limitation of joint models is that they could be computationally expensive for complex models where the number of the shared random effects is large. This package can be used to fit complex multivariate joint models using our newly developed algorithm Jieqi Tu and Jiehuan Sun (2023) <doi:10.1002/sim.9619>, which is based on Gaussian variational approximate inference and is computationally efficient.

Last updated 1 years ago

openblascpp

1.00 score 169 downloads

HDJM - Penalized High-Dimensional Joint Model

Joint models have been widely used to study the associations between longitudinal biomarkers and a survival outcome. However, existing joint models only consider one or a few longitudinal biomarkers and cannot deal with high-dimensional longitudinal biomarkers. This package can be used to fit our recently developed penalized joint model that can handle high-dimensional longitudinal biomarkers. Specifically, an adaptive lasso penalty is imposed on the parameters for the effects of the longitudinal biomarkers on the survival outcome, which allows for variable selection. Also, our algorithm is computationally efficient, which is based on the Gaussian variational approximation method.

Last updated 1 years ago

openblascpp

1.00 score 150 downloads